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外泌体研究必看的经典综述

2017-09-05 09:04:06 作者:小张聊科研 关注:xzlky2015 神评论

关于外泌体这个热点,我们已经写过不少文章介绍过:

从今年国自然的基金的中标情况来看,外泌体相关的研究也确实是资助的重点,共资助302项,资助金额1.24亿。其中青年基金118项,面上项目162项,地区项目19项,重点项目有2项:

  • 外泌体介导的肾癌肺转移前微环境改变调控肿瘤细胞间质上皮转化的机制研究 

  • 基于HIF通路与外泌体非编码RNA的砷暴露所致健康危害机制及风险评估研究 

在这些项目中,与外泌体结合的方向有:miRNA 90项,干细胞 67项,lncRNA 21项,自噬 9项,标志物 9项,circRNA 8项,外泌体载药:6项。在医学部申请各代码的排序如下:

肿瘤干细胞、修复是主要申报领域。


下面我们就梳理下研究外泌体必看的经典综述(影响因子10+,按领域区分):


一、外泌体与肿瘤

1. Versatile roles of extracellular vesicles in cancer.

2.The biology and function of exosomes in cancer.

3. Dendritic cell-derived exosomes for cancer therapy.

4. Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.

5.Exosome-Mediated Metastasis: From Epithelial-Mesenchymal Transition to Escape from Immunosurveillance.

6.Extracellular Vesicles in Angiogenesis.

7. Exosomes in Cancer Nanomedicine and Immunotherapy: Prospects and Challenges.

8.Exosomes and tumor-mediated immune suppression.

二、外泌体与心血管系统疾病

1.Extracellular Vesicles in Metabolic Syndrome.

2.Exosomes in stroke pathogenesis and therapy.

3. Extracellular vesicles in coronary artery disease.

4.Exosomes Generated From iPSC-Derivatives: New Direction for Stem Cell Therapy in Human Heart Diseases.

5.More Than Tiny Sacks: Stem Cell Exosomes as Cell-Free Modality for Cardiac Repair.

6. Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology.

三、外泌体与神经系统疾病:

1.Extracellular vesicles round off communication in the nervous system.

2. Extracellular vesicles and intercellular communication within the nervous system.

四、外泌体与泌尿系统疾病

1.Extracellular vesicles in renal disease.

2.Extracellular Vesicles and Their Role in Urologic Malignancies.

五、外泌体与血液病

The emerging roles of tumor-derived exosomes in hematological malignancies.

六、外泌体与肝病

1.Exosomes in liver pathology.

2.Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases.


七、外泌体与眼病

Roles of exosomes in the normal and diseased eye.

八、外泌体与传染性疾病:

Extracellular vesicles and infectious diseases: new complexity to an old story.

九、外泌体作为载体和研究方法:

1.Extracellular vesicle isolation and characterization: toward clinical application.

2.Extracellular Vesicles: Unique Intercellular Delivery Vehicles.

3.Methodological Guidelines to Study Extracellular Vesicles.

4. Exosomes as Reconfigurable Therapeutic Systems.


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